Figure 1 | Scientific Reports

Figure 1

From: Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

Figure 1

Experimental design for the induction of doxorubicin resistance and metformin treatment. (A) Cells were experimentally induced to doxorubicin resistance through the administration of increasing concentrations (10–100 nM) of doxorubicin. DOX-res: Doxorubicin-resistant group (B) Cells were pretreated with 6 µM metformin for seven consecutive passages before initiating the process of the induction of doxorubicin resistance. Metformin treatment was maintained during the process of chemoresistance induction. Met-DOX: metformin-treated doxorubicin group.

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