Figure 2 | Scientific Reports

Figure 2

From: Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

Figure 2

Metformin prevents the induction of doxorubicin resistance. MTT assay of untreated control group, DOX-res and Met-DOX MCF-7 and MDA-MB231 cells after 24 h of exposure to three doxorubicin concentrations (0.1, 0.5 and 1.0 µM). Data are expressed as mean ± standard deviation of mean. Statistically significant differences were investigated by one-way ANOVA, followed by Tukey post-hoc and p < 0.05 was considered significant. The viability of control group was compared to untreated control group (*p < 0.05 in this comparison). The different concentrations of doxorubicin in Dox-res group were compared with the same concentration in control group (αp < 0.05 in this comparison). The different concentrations of doxorubicin in Met-DOX group were compared with the same concentration in DOX-res group (#p < 0.05 in this comparison). DOX-res: Doxorubicin-resistant group. Met-DOX: metformin-treated doxorubicin group.

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