Figure 3 | Scientific Reports

Figure 3

From: Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

Figure 3

Oxidative profile and related pathways in cells experimentally induced to doxorubicin resistance (DOX-res). (A) Total thiol levels, (B) area under the chemiluminescence curves and (C) peak of the nitric oxide curves in MCF-7 and MDA-MB-231 DOX-res group. (D–F) Quantitative results for nuclear p65-NF-kB, Nrf2 and p53, respectively in MCF-7 and MDA-MB-231 DOX-res group. Data are expressed as mean ± standard deviation of mean. Statistically significant differences were investigated by paired student t test and p < 0.05 was considered significant. *Significantly different from the initial passage (P0′).

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