Table 1 Clinical and biochemical characteristics of patients with chronic hepatitis B (CHB) before and after 5 years of entecavir treatment.
Variable | CHB (n = 114) | Healthy control (n = 88) | p-valuesa | p-valuesb | |
|---|---|---|---|---|---|
Baseline | Year 5 | ||||
Sex (male/female) | 84/30 | — | 59/29 | 0.304c | NA |
Age (years) | 35.1 ± 9.6 | — | 36.4 ± 10.5 | 0.870 | NA |
HBV genotype (B/C/D) | 53/44/17 | — | — | NA | NA |
Metavir score (F0–F1/F2–F3) | 97/17 | — | — | NA | NA |
FIB-4 | 2.15 ± 1.22 | 1.07 ± 0.51 | 0.87 ± 0.37 | 0.000 | 0.016 |
ALT (U/L) | 200.5 ± 102.2 | 21.7 ± 7.3 | 19.6 ± 6.27 | 0.000 | 0.000 |
AST (U/L) | 126.0 ± 63.6 | 19.2 ± 7.8 | 20.7 ± 6.81 | 0.000 | 0.000 |
TB (umol/L) | 15.6 ± 6.1 | 10.8 ± 3.8 | 10.1 ± 3.3 | 0.001 | 0.005 |
ALB (g/L) | 45.6 ± 5.5 | 45.9 ± 5.7 | 48.1 ± 2.5 | 0.012 | 0.692 |
WBC (×109/L) | 4.8 ± 1.2 | 5.4 ± 1.2 | 5.7 ± 1.1 | 0.058 | 0.082 |
PLT (×109/L) | 159.1 ± 57.8 | 190.9 ± 45.9 | 214.1 ± 57.7 | 0.001 | 0.004 |
HBV DNA (log10 IU/mL) | 7.5 ± 1.6 | Undetectable | Undetectable | NA | NA |
HBsAg (log10 IU/mL) | 4.1 ± 0.8 | 3.1 ± 0.6 | Undetectable | NA | 0.002 |
HBeAg (PEIU/mL) | 126.5 ± 65.5 | 0.74 ± 0.4 | Undetectable | NA | 0.000 |
VWF: Ag (U/L) | 1491.4 ± 224.4 | 1060.4 ± 224.8 | 1026.4 ± 255.2 | 0.000 | 0.000 |
ADAMTS13: AC (U/mL) | 815.4 ± 204.4 | 1341.4 ± 267.6 | 1669.2 ± 370.9 | 0.000 | 0.000 |
