Figure 3

Glucose metabolism is impaired after 8 days of HFHF diet. Blood glucose (A1, for 8 days of diet; B1, for 5 weeks of diet and C1, for 13 weeks of diet) and plasma insulin values (A3, for 8 days of diet; B3, for 5 weeks of diet and C3, for 13 weeks of diet) at different times after intraperitoneal administration of glucose solution (2 g/kg body weight). Area under the curve (AUC) values for glucose (A2, for 8 days of diet; B2, for 5 weeks of diet and C2, for 13 weeks of diet) and insulin (A4, for 8 days of diet; B4, for 5 weeks of diet and C4, for 13 weeks of diet) concentrations. Blood glucose (A5, for 8 days of diet; B5, for 5 weeks of diet and C5, for 13 weeks of diet) values at different times after intraperitoneal administration of an insulin solution (0.5 U/kg body weight). Area under the curve (AUC) values for glucose concentrations (A6, for 8 days of diet; B6, for 5 weeks of diet and C6, for 13 weeks of diet). Results are the mean ± SD (n = 8 animals per group). *P < 0.05; **P < 0.01; ***P < 0.001 after Mann-Whitney and ANOVA test followed by Bonferroni test.