Figure 4 | Scientific Reports

Figure 4

From: Detection of Early-Stage Degeneration in Human Articular Cartilage by Multiparametric MR Imaging Mapping of Tissue Functionality

Figure 4

Serial qMRI parameter maps under loading and corresponding histological sections of early degenerative cartilage. For all qMRI parameters, loading-induced increases were observed. Irregular signal hyperintensities (at δ0) became more diffuse and widespread to eventually involve the majority of the sample’s cross-sectional area (in particular T1ρ and T2). Histologically, superficial clefts (indicated by single arrow in e1) and pannus formation (indicated by double arrows in e1) were found alongside diffuse hypercellularity (only visible at higher magnification [not shown]) and severe discoloration on proteoglycan staining. MSS 8. Image details as in Fig. 3.

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