Table 1 MR imaging, histological and biomechanical parameters of human cartilage samples.

From: Detection of Early-Stage Degeneration in Human Articular Cartilage by Multiparametric MR Imaging Mapping of Tissue Functionality

 

Int (n = 27)

Deg (n = 22)

p-values

All (n = 49)

M ± SD

Range

M ± SD

Range

M ± SD

Range

T1

entire cartilage sample (ECS)

734.5 ± 121.3

555.0–1112.0

777.0 ± 104.0

585.3–988.2

ns

753.6 ± 114.7

555.0–1112.0

superficial zone (sf)

784.1 ± 133.8

788.3 ± 100.3

ns

786.0 ± 118.8

deep zone (dp)

684.4 ± 121.2

763.3 ± 123.4

0.029

719.9 ± 127.2

T1ρ

ECS

101.5 ± 16.8

69.0–149.4

98.4 ± 16.2

71.7–150.6

ns

100.2 ± 16.4

69.0–150.6

sf

108.5 ± 18.7

103.7 ± 18.2

ns

106.6 ± 18.4

dp

94.9 ± 18.1

93.0 ± 17.7

ns

94.1 ± 17.7

T2

ECS

40.8 ± 5.4

33.3–56.1

43.1 ± 7.8

32.3–63.6

ns

41.8 ± 6.6

32.3–63.6

sf

46.4 ± 7.0

46.3 ± 9.9

ns

46.3 ± 8.3

dp

35.1 ± 5.8

39.9 ± 7.3

0.008

37.3 ± 6.9

T2*

ECS

22.0 ± 4.3

13.6–31.5

22.0 ± 4.3

15.5–32.0

ns

22.0 ± 4.2

13.6–32.0

sf

23.9 ± 5.2

22.7 ± 5.1

ns

23.4 ± 5.2

dp

19.9 ± 4.3

21.7 ± 6.0

ns

20.7 ± 5.1

Mankin Sum Score

2.4 ± 1.1

0.0–4.0

6.0 ± 0.9

5.0–8.0

<0.001

4.0 ± 2.1

0.0–8.0

Young’s Modulus [MPa]

0.55 ± 0.31

0.19–1.49

0.35 ± 0.34

0.02–1.58

0.003

0.46 ± 0.33

0.02–1.58

  1. Data are given as Mean ± Standard Deviation (M ± SD) or range (minimum – maximum), respectively. P-values indicate, whether group-wise comparisons of histologically intact (int) vs. early degenerative (deg) samples based on the unpaired Student’s t-test after log-transformation were significant or not (ns). Significant group-wise differences are given in bold-type. Units of quantitative MRI parameters: ms. Units of Young’s Modulus: MPa.
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