Figure 6
From: Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
Model simulations for doxorubicin and ROS metabolism. The fate of a single doxorubicin exposure (50 µM) was simulated over a 30-minute time-span in order to glean the resulting transformations between Q, SQ.− and H2Q (top panel). The resulting superoxide and hydrogen peroxide formation and detoxification profiles are illustrated in the bottom left and right panels, respectively.
