Table 1 Comparisons of clinical features and laboratory findings between the normal thyroid group and the thyroid dysfunction group.

From: The relationship between thyroid dysfunction and nephrotic syndrome: a clinicopathological study

 

Normal thyroid

(n = 57)

Thyroid dysfunction

(n = 260)

P

Clinical characteristics

Age (Year)

41.3 ± 14.33

40.65 ± 16.16

0.779

Male (%)

31(54.40%)

139(53.60%)

0.517

Duration of NS (Month)

3.00 [1.00, 8.00]

6.00 [1.00, 10.00]

0.098

HB (g/L)

143.14 ± 23.55

132.24 ± 25.17

0.003

WBC (109/L)

7.36 ± 2.53

8.02 ± 3.41

0.099

PLT (109/L)

202.23 ± 72.02

232.79 ± 86.77

0.014

UA (umol/L)

354.36 ± 87.87

361.52 ± 102.29

0.637

PRO (g/24 h)

4.03 ± 2.45

8.27 ± 6.56

<0.001

PCR (g/mmol Cr)

0.47 ± 0.4

0.9 ± 0.6

<0.001

ALB (g/L)

28.68 ± 6.19

22.08 ± 5.88

<0.001

SCR (umol/L)

55.00 [61.00, 75.5]

70.00 [55.00, 104.95]

0.027

TG (mmol/L)

2.03 ± 1.06

2.46 ± 1.6

0.055

TC (mmol/L)

7.15 ± 2.24

8.48 ± 3.23

<0.001

LDL (mmol/L)

4.54 ± 1.93

5.54 ± 2.78

0.002

FT3 (pmol/L)

4.49 ± 0.64

3.17 ± 1.39

<0.001

TT3 (nmol/L)

1.64 ± 0.26

1.2 ± 0.43

<0.001

FT4 (pmol/L)

15.8 ± 2.18

12.81 ± 3.42

<0.001

TT4 (nmol/L)

87.32 ± 12.8

66.07 ± 25.38

<0.001

TSH (mU/L)

4.57 [2.60, 6.81]

3.00 [2.02, 3.60]

<0.001

RT3 (nmol/L)

0.36 ± 0.14

0.3 ± 0.15

0.215

Coexisting diseases (%)

Hypertension

17.50%

20.20%

0.653

Diabetes

1.80%

5.70%

0.365

Pulmonary infection

7.00%

15.20%

0.157

AKI

1.80%

4.20%

0.624

CKD

1.80%

8.00%

0.163

Renal biopsy (%)

MN

40.4%

30.7%

0.339

MCD

28.1%

36.2%

 

IgAN

10.5%

7.8%

 

MPGN

3.5%

1.9%

 

MsPGN

0.00%

3.50%

 

FSGS

3.5%

3.5%

 

Secondary NS

14.0%

16.3%

 
  1. Data are expressed as mean ± standard deviation, median and interquartile range, or percent frequency, as appropriate.
  2. MN membranous nephropathy, MCD minimal-change disease, FSGS focal segmental glomerulosclerosis, MPGN membrane proliferative glomerulonephritis, MsPGN mesangial proliferative glomerulonephritis, secondary NS secondary reasons of nephrotic syndrome.
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