Table 1 Ratio of circulating Th1 (CD4+IFNγ+): Th2 (CD4+IL4+) cells at gd 4.5 among experimental groups.

From: Low-Dose Tacrolimus Prevents Dysregulated Peri-Conceptional Ovarian and Systemic Immune Cellular Homeostasis in Subjects with PCOS

 

HFD-dNONcNZO

NFD-NONcNZO

Metformin (200 mg/dL)

Tacrolimus (0.1 mg/kg)

#Animals

17

17

17

17

Range

0.95–3.20

0.38–2.13

0.50–1.63

0.41–1.43

Median ±ME

1.40 ± 0.05*

0.94 ± 0.03*

1.17 ± 0.02*

0.83 ± 0.02**

Mean ± SDM

1.58 ± 0.66

1.03 ± 0.45

1.11 ± 0.32†

0.81 ± 0.26†

  1. *p < 0.01 comparing group medians at alpha 0.05 (One-way ANOVA followed by Kruskal-Wallis test).
  2. **p < 0.001 comparing maximal differences between the tacrolimus-treated vs untreated HFD-dNONcNZO group medians at 95% confidence interval (Mann-Whitney U test).
  3. †p = 0.066 comparing maximal differences between the tacrolimus- vs the metformin-treated mice (Mann-Whitney U test).
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