Figure 1

Association between GRS, as based on 52 AMD variants, and the drusen coverage at baseline in the 177 participants of the MARS study with non-advanced AMD at baseline. The red line represents the trend line of the GRS with the area covered by drusen in the ETDRS grid at baseline (β = 1.57, 95% CI 0.75–2.39, P < 0.001). AMD Age related Macular Degeneration; ETDRS Early Treatment Diabetic Retinopathy Study; GRS Genetic Risk Score; MARS Muenster Aging and Retina Study.