Table 2 MBROLE functional pathway enrichment of significantly altered metabolites between Ly6Chi and Ly6Clow macrophages.
From: Multi-omics Analysis of Liver Infiltrating Macrophages Following Ethanol Consumption
MBROLE Pathway Enrichment Analysis | ||||||
|---|---|---|---|---|---|---|
KEGG Pathway | Glycerophospholipid metabolism | p = 0.00000015 | Regulation | FC | Mass | Retention Time |
Metabolite ID | Compound | p ([LOW] vs [HI]) | ||||
HMDB07879 | PC(14:0/20:1) | 0.00000117 | Up | 14552.3 | 759.577 | 2.7959998 |
C05973 | LysoPE(0:0/20:4) | 0.00000004 | Up | 8191.464 | 501.2852 | 1.5950001 |
C05980 | CL(20:4/20:4/18:1/18:1) | 0.02237148 | Up | 2.385773 | 1501.028 | 5.2099996 |
C05980 | CL(16:0/18:1/18:1/18:0) | 0.02935672 | Up | 2.216448 | 1433.044 | 5.2099996 |
C02737 | PS(22:2/20:4) | 0.00619864 | Up | 2.130906 | 863.5636 | 6.431 |
C00416 | PA(14:0/13:0) | 0.01894119 | Up | 2.03645 | 614.3692 | 5.2680006 |
C02737 | PS(18:0/20:3(8Z,11Z,14Z)) | 0.01018467 | Up | 1.82344 | 813.5564 | 5.286 |
C05980 | CL(18:0/18:1/18:1/18:0) | 0.03703265 | Down | −1.59666 | 1461.071 | 6.4690013 |
C05980 | CL(20:1/18:2/18:1/18:1) | 0.02421535 | Down | −1.66882 | 1525.049 | 5.209 |
C05973 | LysoPE(0:0/22:5) | 0.04909987 | Down | −1.78763 | 509.2879 | 1.6539999 |
C05980 | CL(18:0/18:0/18:2/18:0) | 0.03732978 | Down | −2.06192 | 1457.063 | 5.2099996 |
HMDB09093 | PE(18:2/18:2) | 0.00000009 | Down | −6742.01 | 739.5146 | 2.8740003 |
HMDB Pathway | Arachidonic Acid Metabolism | p = 0.025 | Regulation | FC | Mass | Retention Time |
Metabolite ID | Compound | p ([LOW] vs [HI]) | ||||
C00157 | PC(14:0/20:1) | 1.17E-06 | Up | 14552.3 | 759.577 | 2.7959998 |
C00157 | PC(20:3/P-18:1) 7.3700004 | 9.04E-09 | Up | 9632.273 | 793.5885 | 7.3700004 |
C00157 | PC(20:3/P-18:0) | 0.010843969 | Up | 1.91783 | 795.6032 | 7.6989994 |
HMDB04693 | 11H-14,15-EETA | 0.007826052 | Up | 1.674163 | 358.2093 | 1.2530001 |
HMDB04264 | 14,15-Epoxy-5,8,11-eicosatrienoic acid | 0.03620125 | Up | 1.609097 | 320.2328 | 1.1569998 |
C00157 | PC(14:1/P-18:0) | 0.041162275 | Down | −1.38207 | 751.5357 | 5.2099996 |
C00157 | PC(14:1/P-18:0) 5.355 | 0.044275247 | Down | −1.72501 | 751.5351 | 5.355 |
HMDB Pathway | Phospholipid Biosynthesis | p = 0.0000332 | Regulation | FC | Mass | Retention Time |
Metabolite ID | Compound | p ([LOW] vs [HI]) | ||||
C00157 | PC(14:0/20:1) | 1.17E-06 | Up | 14552.3 | 759.577 | 2.7959998 |
C00157 | PC(20:3/P-18:1) 7.3700004 | 9.04E-09 | Up | 9632.273 | 793.5885 | 7.3700004 |
C00350 | PE(18:2/18:2) | 8.68E-08 | Up | 6742.008 | 739.5146 | 2.8740003 |
C02737 | PS(22:2/20:4) | 0.00619864 | Up | 2.130906 | 863.5636 | 6.431 |
C00350 | PE(20:1/20:3) | 0.008398175 | Up | 2.125419 | 795.5765 | 6.4339986 |
C00350 | PE(20:1/20:3) | 0.008398175 | Up | 2.125419 | 795.5765 | 6.4339986 |
C00416 | PA(14:0/13:0) | 0.01894119 | Up | 2.03645 | 614.3692 | 5.2680006 |
C00350 | PE(20:2/P-18:1) | 0.004769958 | Up | 1.966516 | 753.5574 | 7.0680003 |
C00157 | PC(20:3/P-18:0) | 0.010843969 | Up | 1.91783 | 795.6032 | 7.6989994 |
C00350 | PE(14:0/22:1) | 0.02230334 | Up | 1.846544 | 745.5694 | 5.279 |
C02737 | PS(18:0/20:3) | 0.01018467 | Up | 1.82344 | 813.5564 | 5.286 |
C00350 | PE(24:0/P-16:0) | 0.020011874 | Up | 1.637358 | 805.6088 | 7.485 |
C00350 | PE(22:2/P-18:1) | 0.026633823 | Up | 1.515987 | 781.5885 | 7.5039997 |
C00157 | PC(14:1/P-18:0) | 0.041162275 | Down | −1.38207 | 751.5357 | 5.2099996 |
C00350 | PE(14:0/16:0) | 0.032299943 | Down | −1.52035 | 663.4833 | 5.243 |
C00157 | PC(14:1/P-18:0) 5.355 | 0.044275247 | Down | −1.72501 | 751.5351 | 5.355 |
C00350 | PE(14:1/20:4) | 0.009279267 | Down | −1.84186 | 709.4657 | 1.068 |
