Figure 6 | Scientific Reports

Figure 6

From: IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Figure 6

IL-37 reduces pro-inflammatory, and increases anti-inflammatory microglia-macrophages in the brain after stroke. (A) Immunohistochemical quantification of total microglia-macrophages (F4/80+) in the ischemic hemisphere 24 h after stroke. Also shown are numbers of (B) pro-inflammatory (3-nitrotyrosine[3-NT]-positive) and (C) anti-inflammatory (3-NT-negative) F4/80+ cells, and (D) the ratio of F4/80+3-NT+ to F4/80+3-NT− microglia-macrophages in WT and IL-37tg mice. All data are n = 6 and are presented as mean ± S.E.M.; *P < 0.05, unpaired Student’s t-test.

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