Figure 3 | Scientific Reports

Figure 3

From: Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer’s disease

Figure 3

Effect of 20 days pre-treatment with QTC-4-MeOBnE (0.1 and 1 mg/kg i.g.) on oxidative markers and AChE activity of mice submitted to ICV infusion of STZ (3 mg/kg) or saline. TBARS levels in (a) Prefrontal Cortex (PFC) and (b) Hippocampus (HC); Reactive species in (c) PFC and (d) HC; AChE activity, given as nmol/mg protein/min, in (e) PFC and (f) HC. Results are expressed as mean ± SEM. (n = 6–8). ##p < 0.01 and ###p < 0.001 when compared with the control group. **p < 0.01 and ***p < 0.001 when compared to the STZ group (two-way ANOVA followed by Newman-Keuls test).

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