Table 1 Preferential binding of Rh2 to DOPC > eSM > ePC vesicles is accompanied by exo- (DOPC) or endothermic reactions (eSM, ePC).

From: The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol

LUVs

K (mM−1)

∆H (KJ.mol−1)

T∆S (KJ.mol−1)

∆G (KJ.mol−1)

eSM

18.03 ± 7.11

15.88 ± 3.31

49.91 ± 2.43

−34.03 ± 0.93

ePC

4.95 ± 4.65

1.06 ± 0.17

29.42 ± 4.46

−28.36 ± 4.29

DOPC

33.67 ± 1.80

−1.29 ± 0.20

34.47 ± 0.09

−35.75 ± 0.13

  1. Thermodynamic parameters measured by isothermal titration calorimetry for the binding of Rh2 to LUVs composed of eSM, ePC or DOPC at a Rh2/lipid ratio of 0.02 at 25 °C.
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