Figure 1

Estrogen receptor’s (ERα) ligand binding domain (LBD). (a) The LBD consists of twelve α-helices and a beta sheet/hairpin: The twelve α helices (H1-12) are colored differently for better distinguishability; (b) conformation of an active ER and (c) conformation of an inactive ER. The significant difference between (b and c) lies in the H12 conformation, displayed in red color.