Figure 4 | Scientific Reports

Figure 4

From: Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease

Figure 4

Uptake of ASOA19 by various cell types in the mouse brain. Immunostaining images of the (a) substantia nigra and (b–e) striatum of Alexa 488 conjugated-ASOA19-administered wild type mice. Uptake of ASOA19 by neurons, astrocytes, oligodendrocytes, and microglia was seen. ASOA19 was distributed into cells stained with NeuN (a), MAP2 (b), GFAP (c), O4 (d), and Iba1 (e) (arrow). Merged images showing AmNA-Alexa488 in green, NeuN (a), MAP2 (b), GFAP (c), O4 (d), Iba1 (e) in red, and DAPI-labeled cell nuclei in blue. Scale bar: 20 μm.

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