Figure 8
Intracerebroventricular administration of ASOA19 improved motor function in Thy1-SNCA mice. (a) Hanging time for the wire suspension test, which was performed every seven days after treatment with ASOA19 or control. ASOA19-treated mice showed a trend of longer suspension compared with controls. Data are expressed as mean ± SEM (n = 17 ASOA19 and 13 control). (b) The beam walking test was performed four weeks after administration of ASOA19 or control. The graph shows slips per speed. ASOA19-treated mice showed a trend of fewer slips than controls. Data are expressed as mean ± SEM (n = 17 ASOA19 and 13 control). (c) Pasta gnawing test showing the number of bites per gnawing episode every seven days after administration of ASOA19 or control. ASOA19-treated mice showed an increased number of bites, indicating improvement in hypokinetic defects. Data are expressed as mean ± SEM (n = 17 ASOA19 and 13 control). **p < 0.01 by t-test.
