Table 1 Demographics and lung function in 100 subjects with chronic obstructive pulmonary disease (COPD) in Study 1 and another 23 subjects with COPD and 19healthy subjects in Study 2.

From: Developing a New Marker of Dynamic Hyperinflation in Patients with Obstructive Airway Disease - an observational study

 

COPD1

COPD2

Normal

P

mean

SD

mean

SD

mean

SD

COPD Study 1 vs 2

Study 2 COPD vs normal

N=

100

 

23

 

19

   

Age, years

67.8

7.6

68.2

7.7

64.9

9.9

0.93

0.22

Sex: M:F

97:3

 

23:0

 

20:0

   

Height, cm

164.2

6.1

164.8

5

167.1

5.2

0.63

0.14

Weight, kg

61.1

9.6

61.1

10.7

70.5

8.5

0.91

0.003

Body mass index, kg/m2

22.7

3.1

22.5

3.7

25.5

2.7

0.69

0.01

Cigarette smoke, pack × year

46

22.8

69.2

38.5

37.8

40.8

0.0001

0.14

Total lung capacity, TLC, L

6.1#

1

6.25

0.89

5.88

0.81

0.62

0.16

%predicted, %

120

23

115

17

104

13

0.282

0.03

FRC, L

4.4#

1

4.19

1.06

3.14

0.51

0.47

0.0002

%predicted, %

141

35

138

34

102

16

0.69

0.0003

FRC/TLC

0.71#

0.09

0.67

0.1

0.53

0.05

0.04

<0.0001

Residual volume, RV, L

3.5#

1

3.6

1.1

2.42

0.55

0.61

0.0001

%predicted, %

168

54

166

48

112

22

0.83

<0.0001

RV/TLC

0.56#

0.1

0.57

0.11

0.41

0.07

0.77

<0.0001

Inspiratory capacity, IC, L

1.78#

0.55

2.01

0.54

2.75

0.48

0.06

<0.0001

%predicted, %

88

27

82

21

108

19

0.29

0.0004

ICdynamic, L

—

—

2.22∧

0.66

3.03∧

0.69

—

0.003

IC/TLC

0.29#

0.09

0.33

0.09

0.47

0.05

0.09

<0.0001

DLCO, mL/mm Hg/min

14.5

5.2

13.3

5.1

19.2

3.2

0.26

<0.0001

%predicted, %

75#

27

78

21

102

16

0.66

0.0001

Forced vital capacity, FVC, L

2.51

0.65

2.62

0.66

3.45

0.58

0.45

<0.0001

%predicted, %

83

22

83

14

101

13

0.99

0.0002

FEV1, L

1.29

0.46

1.53

0.54

2.76

0.47

0.02

<0.0001

%predicted, %

55

19

64

16

104

12

0.03

<0.0001

FEV1/FVC

0.52

0.12

0.57

0.11

0.8

0.05

0.02

<0.0001

Slow vital capacity, SVC, L

2.7&

0.66

2.66

0.64

3.46

0.57

0.88

<0.0001

%predicted, %

88

24

80

14

99

13

0.11

<0.0001

MVV, L/min

43

17.8

63.5

22.4

108.6

21.1

<0.0001

<0.0001

  1. Functional residual capacity, FRC; Inspiratory capacity, IC; Diffusing capacity for carbon monoxide, DLCO; Forced expired volume in one second, FEV1; MVV. Maximum voluntary ventilation,GOLD I, n = 10; GOLD II, n = 49; GOLD III, n = 32; GOLD IV, n = 9. #n = 97, ICdyn: IC dynamic, measured during incremental exercise testing, &n = 99, *Study 1vs2 on subjects with COPD; ∧p = 0.12 and 0.14, respectively, intra-group comparison.
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