Table 3 Commonly-enriched pathways between CAPN5-NIV and other vitreoretinal diseases: Differentially-expressed pathways in CAPN5-NIV vitreous (compared to controls) that have been previously-identified in proteomic studies of other vitreoretinal diseases. AMD, age-related macular degeneration; PDR, proliferative diabetic retinopathy; PVR, proliferative vitreoretinopathy; RRD, rhegmatogenous retinal detachment.
From: Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy
Pathway | CAPN5-NIV | AMD | PDR | PVR | RRD | Uveitis |
|---|---|---|---|---|---|---|
Acute phase response signaling | Enriched | |||||
Complement cascade | Enriched | Enriched31 | Enriched57 | Enriched58 | Enriched56 | |
Oxidative stress defense | Downregulated | Enriched31 | Downregulated57 | Downregulated58 | ||
Synaptic transmission | Downregulated | Enriched56 | ||||
VEGF and PDGF signaling | Enriched2 | Enriched53 | Enriched51 | Enriched9 | ||
mTOR and PI3K signaling | Enriched2 | Enriched51 |
