Figure 4 | Scientific Reports

Figure 4

From: Effect of mycalolides isolated from a marine sponge Mycale aff. nullarosette on actin in living cells

Figure 4

Effects of the fraction 11-3(1) (82% mycalolide A) on cytokinesis. (A–D) Live cell imaging. Phase-contrast images of HeLa cells were collected every 10 min, and 10 ng/ml mycalolide A was added at time point 00:00 (hh:mm). Large images are composited from 9 (3 × 3) original images next to each other. Bar, 10 μm. (A,B) Images just before (A) and after (B) the addition of mycalolide A. (C) Time-lapse images of a cell (indicated in (B)) that went into mitosis. (D) Cells at 8:50 after mycalolide A addition. Cells that failed to complete cytokinesis and harbored two nuclei are indicated by circles.

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