Figure 3

The contribution (%) of each sub-pathway to total (a) progesterone (P4) effects – i.e. the proportion of corresponding metabolites which were hormonally responsive, (b) day effects – i.e. the proportion of corresponding metabolites which were temporally dynamic, (c) day by P4 interactions – i.e. the proportion of corresponding metabolites whose concentrations differed between groups (normal vs. high P4) at different times (Days 12 vs. 13 vs. 14), and (d) abundance – i.e. the size of the sub-pathway. Abbreviations: progesterone (P4), super-pathways: energy metabolite (E), nucleotide metabolite (N), vitamin and cofactor metabolite (VC), xenobiotic (X), and peptide (P).