Table 2 List of differential metabolites for discrimination among the CV, MV, CF, and MF groups from serum analysis.

From: A comprehensive metabolomics investigation of hippocampus, serum, and feces affected by chronic fluoxetine treatment using the chronic unpredictable mild stress mouse model of depression

t_R (min)	Metabolite	Formula	Ionization mode	Measured m/z	Mass error (mDa)	MV vs. CV		MF vs. MV		CF vs. CV
t_R (min)	Metabolite	Formula	Ionization mode	Measured m/z	Mass error (mDa)	Fold change	VIP score	Fold change	VIP score	Fold change	VIP score
1.22	L-Leucine/L-Isoleucine	C₆H₁₃NO₂	POS	132.1008	−1.7	0.79	10.0			1.72	7.4
1.41	Tyramine^a	C₈H₁₁NO	POS	160.0747	0.9			0.04	11.9	0.04	14.8
2.00	L-Tryptophan	C₁₁H₁₂N₂O₂	POS	205.0965	−1.2					0.66	9.7
			NEG	203.0822	0.1					0.42	4.5
2.48	Indoxyl sulfate	C₄H₈NO₇P	NEG	212.0016	5.6	2.61	7.17
3.90	5-Thymidylic acid	C₁₀H₁₅N₂O₈P	NEG	321.0432	−5.6	2.07	6.03
11.73	β-Citryl-L-glutamic acid^b	C₁₁H₁₅NO₁₀	NEG	641.1373	5.9	0.57	5.41	237.34	9.0	103.00	9.9
11.74	LysoPC(16:1)	C₂₄H₄₈NO₇P	POS	494.3240	−0.7	0.59	13.0			2.74	6.2
12.48	LysoPE(0:0/18:2)	C₂₃H₄₄NO₇P	POS	478.2922	−1.2	1.69	12.4	1.28	6.7
			NEG	476.2781	0.4	1.52	6.12			0.56	3.8
12.59	LysoPE(0:0/20:2)	C₂₅H₄₈NO₇P	NEG	504.3099	0.9	1.41	11.77	0.78	7.7	0.80	3.5
12.59	LysoPC(18:2)	C₂₆H₅₀NO₇P	POS	520.3408	0.5	1.18	29.7			0.93	13.3
12.68	LysoPC(20:4)	C₂₈H₅₀NO₇P	POS	544.3404	0.1	0.63	23.3	0.58	14.5	0.81	12.8
12.68	LysoPE(0:0/22:4)	C₂₇H₄₈NO₇P	NEG	528.3098	0.8			0.54	5.0
13.40	LysoPC(15:0)	C₂₃H₄₈NO₇P	NEG	480.3085	−0.5			0.66	10.0	0.70	9.6
13.40	LysoPC(16:0)	C₂₄H₅₀NO₇P	POS	496.3403	0.0			0.34	23.9
13.51	LysoPC(20:3)	C₂₈H₅₂NO₇P	POS	546.3554	−0.6	0.77	8.4
14.10	LysoPE(0:0/20:1)	C₂₅H₅₀NO₇P	NEG	506.3244	−0.3	0.71	10.52
14.10	LysoPC(18:1)	C₂₆H₅₂NO₇P	POS	522.3551	−0.9			0.60	20.6	0.76	17.7
15.89	Hydrocinnamic acid^c	C₉H₁₀O₂	POS	301.1401	−3.9			1.53	6.4	1.48	11.4
19.24	Docosahexaenoic acid	C₂₂H₃₂O₂	NEG	327.2317	−1.6	0.37	4.78

^a[M+Na]⁺.
^b[2M-H]⁻.
^c[2M+H]⁺.

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