Table 1 Top ranked genes from MAGeCK analysis.
From: Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031
MAGeCK rank | gemcitabine | NUC-1031 | ||||||
|---|---|---|---|---|---|---|---|---|
Negative selection | Positive selection | Negative selection | Positive selection | |||||
Day 14 | Day 21 | Day 14 | Day 21 | Day 14 | Day 21 | Day 14 | Day 21 | |
1 | CSF3R | NAA10 | PP1R32 | TSC2 | TSC2 | hsa-mir-555 | TMEM165 | TMEM165 |
2 | LRRC24 | POLR2D | hsa-mir-4711 | CRYGC | ZBTB46 | TSC2 | DCK | DCK |
3 | POLB | PELO | NCOA3 | ATRNL1 | TSC1 | DMPK | PYCR2 | NTC_0397 |
4 | MBLAC2 | RPL14 | CENPE | SH3BP4 | ZNF281 | PCOLCE | DCTPP1 | SIRPD |
5 | NPBWR1 | HPS5 | UGGT2 | hsa-mir-6727 | COL4A1 | OR10A5 | SYNCRIP | TSPAN12 |
6 | COG7 | HM13 | ARL1 | MAP4K5 | DDIT4 | RUFY1 | NTC_0731 | HCN3 |
7 | CTTNBP2 | WDR43 | hsa-mir-548h-5 | hsa-mir-1254-2 | OR51E2 | hsa-mir-185 | RASSF7 | POMP |
8 | TNFRSF1A | COX5A | UBXN2A | NTC_0555 | PHTF1 | OR1M1 | NACC2 | NTC_0203 |
9 | WWP2 | XRCC5 | NADK2 | hsa-mir-1265 | ERBB2IP | CCDC42B | NTC_0040 | NTC_0045 |
10 | ATP6V1B1 | KIAA1239 | CLEC19A | CDH29 | LHPP | KCNA3 | COQ4 | DDO |
