Figure 1

Serum levels of damage-associated enzymes increases concomitantly with IL-1α production in the liver during P. chabaudi malaria. Mice were infected with 1 × 10⁶ P. chabaudi-iRBCs. Non-infected mice (day 0) were used as controls. (A,B) The parasitemia curve and the serum AST, ALT and LDH concentrations in C57BL/6 mice. The data are expressed as the means ± SD (n = 3) of one representative experiment out of three. (C) Il1a mRNA levels in the liver tissue of C57BL/6 mice. FC, fold change. (D) IL-1α levels in the liver cell supernatants from C57BL/6 mice. (E) IL-1α levels in the liver cell supernatants from C57BL/6, Nlrp3^−/− and Casp1/11^−/− mice. (C–E) The data were pooled from three independent experiments (n = 4–12). Significant differences were observed between non-infected and infected mouse groups with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001, using the Kruskal-Wallis multiple comparison test.