Figure 2
From: IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria
IL-1α production is associated with liver inflammation and necrosis caused by acute P. chabaudi malaria. C57BL/6 mice were infected with 1 × 106 P. chabaudi-iRBCs. Non-infected mice (day 0) were used as controls. (A) H&E-stained liver sections showing necrotic foci (n), cellular infiltration (black arrows), extramedullary hematopoiesis (white arrows), hemozoin pigments (hz) and portal vein (pv). Original magnification is 5x (bar scale corresponds to 300 μm) and 20x (scale bar corresponds to 50 μm). (B) Semiquantitative histopathological scores of inflammation, necrosis and total histopathology (inflammation and necrosis). The data are expressed as the means ± SD (n = 3) of one representative experiment out of two. Significant differences were observed between non-infected and infected mouse groups with *p < 0.05, **p < 0.01 and ***p < 0.001, using the Kruskal-Wallis test multiple comparison test.
