Figure 4
Quantification of axonal damage following mFPI. Common features (undulations, varicosities, and terminal bulbs) associated with diffuse axonal injury were evident following fluid percussion injury in mice. At each time-point the percentage of axons with each type of feature was quantified. (a) At 1 hr post-injury, mFPI mice had significantly more undulated axons than sham-injured animals (***p = 0.002). (b) At 3, 7 and 14 days post-injury, mFPI mice had a significantly higher percentage of axons with varicosities than sham-injured mice (****p < 0.0001, ****p < 0.0001, **p = 0.0012, respectively). (c) There was no statistical difference between sham and mFPI mice in the percentage of axons with terminal bulbs at any time-point. (Two-way ANOVA with Sidak correction.)
