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Figure 1

From: Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

Figure 1

Expression of PDE5 and cGK in the vessel wall. (a) Representative figures of the expression patterns of PDE5 and cGK in various organs using immunohistochemistry. Strong expression of both PDE5 and cGK were observed in the smooth muscle cell layer of the vessel wall and in the rat penile tissue. Compared to the intensity of these markers, the heart showed weaker expression (n = 3). (b) In the human heart, the smooth muscle layer of the coronary artery strongly expressed both PDE5 and cGK (n = 10).

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