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Figure 2

From: Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

Figure 2

Inhibitory effect of sildenafil on neointimal formation after angioplasty. (a) Representative figures of the vessels at 2 weeks after balloon injury in rat carotid arteries (n = 10). Compared to the vehicle-treated group, the sildenafil-treated group significantly reduced neointimal hyperplasia. I = Intima, M = Media, A = Adventitia. Scale bar = 200 µm. (b) Quantitative graphs of Intima to Media (I/M) ratio and intimal area at 2 weeks after balloon injury. Graphs show significantly reduced I/M ratio and intimal area in the sildenafil-treated group (n = 10). **P < 0.01.

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