Figure 2
From: Systems Pharmacogenomic Landscape of Drug Similarities from LINCS data: Drug Association Networks
Similarity distribution of drugs over different experiments. (A) Distribution of JI of all significant interactions for Napproved from profiles having between 100–150 DEGs. (B) Distribution of JI of all significant interactions for Nall from signature profiles having DEGs between 700–800. (C) Number of significant interactions between drugs for different cell lines. (D) Heat map showing drug similarities using JI for selected drug-pairs (y-axis) in dependence on cell lines (x-axis) having a JI larger than 0.5 and appearing in ten or more experiments. The color indicates the value of the JI for drug-pairs. The grey color shows drug-pair not available in a given cell line.
