Figure 3 | Scientific Reports

Figure 3

From: Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model

Figure 3

Newly-generated HCs express multiple hair cell proteins. New hair cell generation is observed two weeks following injection of 5-aza into the deafened mouse inner ear. These cells simultaneously express multiple hair cell specific proteins Myosin VIIa, Myosin VI and Pou4f3. Myosin VIIa and Myosin VI are found to co-express in the new HC-like cells (arrows). Myosin VIIa and Pou4f3 co-labeling is found in some cells (arrows), whereas some cells only express either Myosin VIIa (arrowheads) or Pou4f3 (double arrow). Scale bar: 50 μm in cochlear section overview; 20 μm in organ of Corti (OC) highlight.

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