Figure 4 | Scientific Reports

Figure 4

From: Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model

Figure 4

Generation of new hair cells by 5-aza is concentration dependent. (a) Deafened mice received 0.4, 1, 4 and 40 mM 5-aza injection and maintained for 2 weeks after injection. New Myosin VIIa-expressing HCs are observed in deafened mouse inner ear in 5-aza treated inner ear (arrows for the IHC area and arrowheads for the OHC area). Flask-like shape cells are observed in the IHC area (arrows), whereas columnar-shaped cells are found in the OHC area (arrowheads). Scale bar: 50 µm in cochlear section overview; 20 µm in organ of Corti (OC) highlight. (b) Quantification of the number of new OHCs in cochlear section in each 5-aza concentration group.

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