Figure 1 | Scientific Reports

Figure 1

From: Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

Figure 1

Podocyte loss downregulates complement regulatory factors. (a) NEP25/LMB2 mice (12 days after LMB2 exposure, n = 3) showed fibrin deposition and epithelial cell hyperplasia without IC deposition. Magnification, x400. (b) qRT-PCR analysis of isolated glomeruli showed that podocyte loss induced a decrease in complement regulating factor mRNAs. NEP25/PBS (n = 3), NEP25/LMB2 (Day 12, n = 3), NEP25/LMB2 (Day 5, n = 3). *p < 0.05. CFH; Complement factor H, CFI; complement factor I, DAF; decay-accelerating factor, Crry; complement receptor 1-related gene/protein y, C3aR; C3a receptor, C5aR; C5a receptor.

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