Table 6 Effect of dextrose gel dose on interstitial glucose parameters in 6-hour epochs following hypoglycemia.

From: Factors influencing glycaemic stability after neonatal hypoglycaemia and relationship to neurodevelopmental outcome

 

Dextrose gel dose

≥2 doses (>200 mg/kg)

1 dose (≤200 mg/kg)

Mean difference [95% Confidence Intervals]

Number of 6-hour epochs

32

65

 

Number of babies

22

46

 

Blood glucose at the onset of the epoch*

2.1 (0.3)

2.2 [1.9; 2.3]

2.2 (0.3)

2.3 [2.1; 2.5]

−0.15 [−0.28; −0.01]

Number of blood glucose concentration <2.6 mmol/l per epoch

2 [2; 3]

1 [1; 1]

 

Hours to maximum IG

3.8 (1.7)

3.7 [2.4; 5.4]

3.2 (1.6)

3.0 [2.0; 4.4]

0.55 [−0.15; 1.24]

Average IG**

3.0 (0.5)

3.0 [2.6; 3.3]

3.4 (0.6)

3.3 [3.0; 3.7]

−0.39 [−0.62; −0.15]

Maximum IG

4.1 (1.3)

3.8 [3.4; 4.3]

4.1 (0.9)

4.0 [3.4; 4.6]

−0.04 [−0.50; 0.41]

Minimum IG*

2.1 (0.4)

2.2 [1.8; 2.3]

2.2 (0.3)

2.3 [2.1; 2.5]

−0.17 [−0.32; −0.02]

IG range

2.0 (1.5)

1.6 [1.2; 2.1]

1.9 (0.9)

1.6 [1.3; 2.4]

0.12 [−0.36; 0.61]

Proportion IG outside central band of 3–4 mmol/l*

0.63 (0.30)

0.68 [0.37; 0.90]

0.51 (0.27)

0.53 [0.28; 0.72]

0.12 [0.00; 0.24]

Duration (hours) IG <2.6 mmol/l***

2.28 (1.48)

1.91 [1.18; 3.63]

0.97 (0.97)

0.65 [0.39; 1.28]

0.87 [0.51; 1.23]

  1. Data are number, median [interquartile range], mean (standard deviation), or mean difference [95% confidence intervals]. IG, interstitial glucose concentration. Glucose concentrations are expressed as mmol/l. *P < 0.05, **P < 0.01, ***P < 0.001 for comparison between ≥ 2 and 1 gel doses.