Table 7 Interstitial glucose parameters in 6-hour epochs with intravenous dextrose treatment.

From: Factors influencing glycaemic stability after neonatal hypoglycaemia and relationship to neurodevelopmental outcome

 

Bolus (yes vs no)

GDR (mg/kg/min)

Dextrose gel (yes vs no)

3234 weeks’ gestational age:

Epochs (babies) N = 10 (9)

Hours to maximum IG

0.44 [−1.70; 2.58]

−0.12 [−0.44; 0.19]

−1.25 [−3.85; 1.34]

Average IG

−0.08 [−2.98; 2.82]

−0.09 [−0.53; 0.35]

0.33 [−3.10; 3.76]

Maximum IG

0.05 [−5.68; 5.78]

0.00 [−0.83; 0.84]

0.15 [−6.80; 7.12]

Minimum IG

−0.50 [−2.28; 1.28]

−0.17 [−0.50; 0.10]

−0.12 [−2.21; 1.96]

IG range

0.85 [−4.70; 6.39]

0.11 [−0.70; 0.91]

0.45 [−6.27; 7.17]

Proportion IG outside central band of 3–4 mmol/l

0.30 [−0.36; 0.97]

0.07 [−0.03; 0.17]

0.67 [−0.12; 1.46]

Duration (hours) IG <2.6 mmol/l

1.46 [−0.52; 3.44]

0.21 [−0.10; 0.51]

0.02 [−1.49; 3.14]

≥35 weeks’ gestational age:

Epochs (babies) N = 36 (19)

Hours to maximum IG

−0.53 [−1.87; 0.82]

−0.08 [−0.35; 0.20]

−0.16 [−1.71; 1.39]

Average IG

−0.23 [−0.83; 0.36]

0.00 [−0.12; 0.13]

−0.76 [−1.46; −0.06]*

Maximum IG

0.04 [−1.12; 1.19]

−0.05 [−0.29; 0.19]

−0.38 [−1.74; 0.97]

Minimum IG

−0.33 [−0.60; −0.07]*

0.00 [−0.05; 0.06]

−0.39 [−0.69; −0.08]*

IG range

0.37 [−0.82; 1.56]

−0.06 [−0.31; 0.19]

0.00 [−1.39; 1.39]

Proportion IG outside central band of 3–4 mmol/l

0.09 [−0.11; 0.28]

0.02 [−0.02; 0.06]

0.25 [0.02; 0.48]*

Duration (hours) IG < 2.6 mmol/l

0.39 [−0.21; 0.99]

−0.02 [−0.14; 0.10]

1.03 [0.34; 1.72]**

  1. Data are regression coefficient [95% confidence interval]. Adjusted for time when IV was started; IG, interstitial glucose concentration; GDR, glucose delivery rate. Glucose concentrations are expressed as mmol/l. *P < 0.05, **P < 0.01.