Table 2 Cox proportional hazard analyses for the risk factors of colorectal neoplasm occurrence at the surveillance colonoscopy in the matched cohort.

From: Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis

Variables

Overall CRN occurrence (n = 119 from 420 matched cohort, 28.3%)

Advanced CRN occurrence (n = 13 from 420 matched cohort, 3.1%)

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

Sex (Men)

1.99 (0.87–4.58)

0.10

2.73 (1.14–6.53)

0.02

1.07 (0.14–8.25)

0.95

1.70 (0.20–14.57)

0.63

Age (Years)

1.02 (1.01–1.04)

0.007

1.01 (0.98–1.03)

0.64

1.08 (1.03–1.14)

0.002

1.08 (1.03–1.14)

0.003

BMI (kg/m2)

0.97 (0.91–1.02)

0.25

0.93 (0.88–0.98)

0.01

0.91 (0.77–1.09)

0.31

0.92 (0.77–1.11)

0.41

Current or past- Smoking

1.50 (1.01–2.25)

0.05

0.33 (0.87–2.03)

0.18

0.90 (0.30–2.77)

0.86

0.95 (0.27–3.39)

0.94

Family history of CRC

1.25 (0.51–3.07)

0.63

1.21 (0.47–3.14)

0.69

4.5 (1.00–20.34)

0.051

7.06 (1.28–39.09)

0.03

Hypertension

1.69 (1.17–2.44)

0.005

2.05 (1.38–3.04)

<0.001

2.73 (0.92–8.15)

0.07

1.80 (0.44–7.42)

0.41

Diabetes

1.61 (0.99–2.61)

0.05

1.46 (0.88–1.42)

0.14

1.29 (0.29–5.85)

0.74

1.24 (0.23–6.74)

0.80

Aspirin or NSAIDs use

1.04 (0.62–1.74)

0.89

0.67 (0.38–1.18)

0.16

2.71 (0.83–8.83)

0.10

1.58 (0.40–6.22)

0.52

Lipid lowering agent

1.07 (0.57–2.00)

0.84

0.75 (0.37–1.54)

0.43

0.75 (0.10–5.81)

0.78

0.49 (0.05–5.13)

0.56

Significant alcohol consumption

1.68 (1.16–2.43)

0.006

1.86 (1.28–2.70)

0.001

1.32 (0.44–3.94)

0.62

1.72 (0.53–5.53)

0.36

Index colonoscopy findings

 

0.005

 

0.005

 

0.001

 

0.007

Normal risk

Reference

 

Reference

 

Reference

 

Reference

 

Low risk

1.41 (0.91–2.19)

0.12

1.29 (0.83–2.01)

0.26

1.28 (0.25–6.59)

0.77

0.69 (0.12–3.93)

0.68

High risk

2.24 (1.37–3.68)

0.001

2.26 (1.38–3.73)

0.001

8.77 (2.67–28.79)

<0.001

5.16 (1.51–17.61)

0.009

  1. BMI, body mass index; CRC, colorectal cancer; NSAID, non-steroidal anti-inflammatory drugs; CRN, colorectal neoplasm; HR, hazard ratio; CI, confidence interval. In the multivariate analysis, sex, age, BMI, smoking, family history of CRC, hypertension, diabetes, aspirin, NSAIDs, or lipid lowering agent usage, proportion of patients with significant alcohol consumption, and index colonoscopy findings were controlled. Significant alcohol consumption was defined as more than 20 g/day in women and 30 g/day in men. Risk category of index colonoscopy was defined as normal (no adenoma), low- (1 or 2 adenomas less than 10 mm)-, and high- (advanced adenoma or more than 3 adenomas) risk groups.
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