Table 2 Descriptive (mean (95% CI)) and comparative statistics of each ROI pair in each cohort for the TD vs. CST wiring group comparison.

From: Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy

 

TD cohort (n = 60)

Contralateral CST (n = 9)

Bilateral CST (n = 6)

Ipsilateral CST (n = 9)

Wilk’s Lambda (p)

F (p)

group*connection

main effect group

Intra functional connectivity non-dominant hemisphere

0.95 (0.63)

0.93 (0.43)

M1-PMd

0.33 (0.05)

0.35 (0.15)

0.35 (0.26)

0.24 (0.08)

  

M1-PMv

0.03 (0.03)

0.12 (0.11)

0.03 (0.04)

0.09 (0.10)

  

M1-S1

0.69 (0.06)

0.77 (0.20)

0.70 (0.16)

0.68 (0.17)

  

Intra functional connectivity dominant hemisphere

0.79 (0.005)*

 

M1-PMd

0.30 (0.06)

0.56 (0.21)

0.42 (0.22)

0.23 (0.10)

4.16 (0.009)†,§

 

M1-PMv

0.03 (0.03)

0.09 (0.13)

0.18 (0.13)

0.15 (0.11)

3.59 (0.02)

 

M1-S1

0.87 (0.07)

0.77 (0.17)

0.99 (0.43)

0.77 (0.19)

0.88 (0.45)

 

Inter functional connectivity Les → NonLes

0.89 (0.37)

0.47 (0.70)

M1-PMd

0.19 (0.05)

0.27 (0.13)

0.28 (0.19)

0.24 (0.16)

  

M1-PMv

0.05 (0.03)

0.06 (0.09)

0.10 (0.07)

0.10 (0.13)

  

M1-S1

0.40 (0.06)

0.28 (0.11)

0.34 (0.11)

0.39 (0.12)

  

M1-SMA

0.32 (0.06)

0.21 (0.13)

0.29 (0.16)

0.35 (0.18)

  

Inter functional connectivity NonLes → Les

0.87 (0.29)

0.03 (0.99)

M1-PMd

0.22 (0.04)

0.28 (0.14)

0.28 (0.15)

0.22 (0.13)

  

M1-PMv

0.01 (0.03)

0.07 (0.18)

0.03 (0.04)

0.14 (0.14)

  

M1-S1

0.38 (0.06)

0.40 (0.16)

0.34 (0.10)

0.32 (0.11)

  

M1-SMA

0.29 (0.06)

0.17 (0.10)

0.30 (0.14)

0.21 (0.16)

  

M1-M1

0.47 (0.07)

0.43 (0.13)

0.47 (0.13)

0.50 (0.11)

 

0.10 (0.96)

  1. TD, typically developing; uCP, unilateral cerebral palsy; CST, corticospinal tract; M1, primary motor cortex; PMd, dorsal stream of the premotor cortex; PMv, ventral stream of the premotor cortex; S1, primary sensory cortex; SMA, supplementary motor area. *Statistically significant (p < 0.05). Contralateral CST vs. Ipsilateral CST; §Contralateral CST vs. TD group.