Table 2 FGF20 levels following 10 µM drug treatment in MCF-7 cells.

From: Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats

Candidate

FGF20 fold increase

SEM

P value

 

dimethadione

4.40

0.87

0.0095

**

trazodone

2.68

0.23

0.0024

**

salbutamol

2.69

0.13

0.0002

***

atenolol

2.92

0.49

0.013

*

propranolol

4.29

0.50

0.002

**

levonorgestrel

3.38

1.03

0.067

 

sitosterol

2.19

0.93

0.189

 

clonidine

2.99

0.71

0.013

*

luteolin

2.06

0.32

0.019

*

torsemide

3.92

1.20

0.036

*

estriol

2.09

0.41

0.05

 

triflusal

3.72

0.78

0.003

**

ethaverine

3.65

0.66

0.013

*

betamethasone

2.29

0.81

0.08

 

testosterone

2.57

0.48

0.016

*

equilin

2.39

0.76

0.16

 
  1. Drugs in bold were taken forward into ventral mesencephalic primary culture studies. P value obtained by Student’s t-test analysis between drug treatment and individual vehicle controls. *, ** and *** are P values < 0.05, <0.01 and <0.001, respectively.
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