Figure 3
Fingolimod reduces blood lymphocyte counts and lymphocyte infiltration to the ischemic brain. (a) Fingolimod induced a strong reduction of T (96%) and B (90%) lymphocytes in the blood 24 h post-ischemia (mean ± SD, n = 4 per group) T cells: 295.8 ± 203.4 cells/μl in the vehicle group and 10.25 ± 4.4 cells/μl in the fingolimod group (Mann-Whitney test, *p = 0.028); B cells: 664.8 ± 737.9 cells/μl in the vehicle group and 61.5 ± 8.7 cells/μl in the fingolimod group (Mann-Whitney test, *p = 0.028). However, it did not modify myeloid cell counts, except for an increase in neutrophils that did not reach statistical significance (Mann-Whitney test, p = 0.200). (b) Fingolimod reduced lymphocyte infiltration to the ischemic brain tissue (Mann-Whitney test, *p = 0.029). Bars correspond to the mean ± SEM and symbols show the value of each mouse.
