Table 1 Parameters used for the bone regeneration model.
Param. | Value | Description |
|---|---|---|
T | 12 months | Period of bone regeneration considered in the model |
L | 30 mm | Length of bone defect/scaffold considered in the model |
γ | 1% | Hard-loaded engineering strain |
D(ρ) | k5(1 − ρ) | Diffusivity of bioactive molecules in the scaffold occupied defect site |
\({\mathbb{C}}(\rho ,\sigma ,b)\) | ρσ + k6b | Elastic modulus for the scaffold/regenerated bone material composite |
k 1 | 0.1 per month | PCL absorption rate constant |
k 2 | k3/γ | Generation rate of bioactive molecules |
k 3 | 80 per month | Decay rate of bioactive molecules |
k 4 | 0.25/γ per month | Rate of bone regeneration (healthy individual) |
k 5 | 100(μm)2/s ≈ 260 (mm)2/month | Diffusivity of bioactive molecules without scaffold |
k 6 | 9.0 | Relative modulus of bone vs. scaffold |
