Table 1 Amoebicidal activity and cytotoxicity of the synthetic compounds.

From: Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue

Compound*

Chemical Structure

IC50 vs E. histolytica

IC50 vs Vero Cells

SI

T-001

1.41

>100

>70.92

T-011

0.35

5.86

16.74

T-016

1.47

>100

>68.02

Mtz

4.50

>100

>22.22

  1. *Duque-Montaño et al., 2013.
  2. IC50 in µM.
  3. Mtz: Metronidazole.
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