Table 3 Summarized linear mixed effects models for antidepressants x PSRS interaction in the PSRS subsample.

From: Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach

 

Lat. OFC surf.

Paracentral lob. surf.

Postcentral gyr. surf.

Precentral gyr. surf.

F

P-value

F

P-value

F

P-value

F

P-value

FEP, CHR-P, HC with PSRS

Age

4.6873

0.0341

0.869

0.3548

3.3973

0.07

0.517

0.4748

ADeq x PSRS

7.0471

0.0095*

10.8924

0.0014*

9.3919

0.0028*

9.848

0.0023*

ADeq x PSRS x hemisphere

4.4517

0.0384

2.5105

0.1177

0.2056

0.6517

0.0081

0.9286

Antidepressants dose

2.9211

0.0923

3.5752

0.0632

4.08

0.0477

4.7202

0.0335

Diagnosis

0.0452

0.9559

0.5532

0.5778

0.2971

0.744

0.5067

0.6049

Hemisphere

0.1085

0.7428

0.2191

0.6412

0.0045

0.9466

0.1297

0.7198

PSRS

0.0187

0.8917

0.1503

0.6996

0.5883

0.4459

0.474

0.4937

Sex

1.1951

0.2784

0.0795

0.7788

0.0593

0.8085

0

0.9999

FEP and CHR-P with PSRS

Age

3.8094

0.0565

0.6519

0.4232

4.1523

0.0468

0.4273

0.5163

ADeq x PSRS

7.0548

0.0098*

10.3231

0.002***

11.4315

0.0011***

10.5822

0.0017***

ADeq x PSRS x hemisphere

4.2635

0.0436

2.4821

0.121

0.1726

0.6795

0.0039

0.9504

Antidepressants dose

2.8239

0.099

3.0493

0.0869

4.1067

0.048

4.1415

0.0471

Diagnosis

0.0009

0.9765

0.6933

0.4089

0.0878

0.7681

0.5546

0.4599

Hemisphere

0.0433

0.8359

0.1112

0.7401

0.0638

0.8015

0.0194

0.8896

PSRS

0.1816

0.6718

0.2093

0.6493

1.8401

0.1808

1.5295

0.2219

Sex

0.6018

0.4415

0.0055

0.9412

1.0283

0.3154

0.1753

0.6772

  1. *P-value < 0.01, ***survived correction for FDR with P-value < 0.05, OFC: orbito-frontal cortex, lat.: lateral, surf: surface, vol.: volume, ADeq: antidepressant medication fluoxetine equivalents, PSRS: polygenic schizophrenia risk score.
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