Figure 5
From: Robust dynamical invariants in sequential neural activity
Results of blocking fast inhibitory synapses with PTX. Panel (A) Scheme of the connectivity of the pyloric CPG after applying picrotoxin (PTX) \(5\cdot {10}^{-7}\,M\). Dotted lines correspond to blocked fast inhibitory synapses. Panel (B) Example of the spiking-bursting activity of the circuit after applying PTX. The traces correspond to simultaneous intracellular recordings of PD (upper trace) and LP (lower trace) neurons. Note that the characteristic IPSPs typical seen in the PD neuron trace are no longer present. Panel (C) Coefficient of variation (\({C}_{v}\)) for the six measures in three conditions: control, first column for each measure (darkest color); after applying PTX \(5\cdot {10}^{-7}\,M\) (\(N\) = 3), middle column; after adding ethanol to the PTX dilution (\(N\) = 3), third column (lightest hue boxes). The highest variability in control conditions corresponded to \(B{D}_{LP}\) and \(PDLP\,delay\) \(\mathrm{(15 \% )}\), while after applying PTX the highest \({C}_{v}\) corresponded to \(LPPD\,delay\) with \(\mathrm{163 \% }\), which is almost 14 times higher than in control. Variability in the other 5 measures also increased with PTX although more slightly. Adding ethanol to the PTX solution increased variability even further (43–201%).
