Table 2 Fine and Gray regression model for demographic and clinical factors associated with CRC mortality.
From: The effects of comorbidity on colorectal cancer mortality in an Australian cancer population
*M1 | **M2 | ***M3a | M3b | M3c | |
|---|---|---|---|---|---|
Crude sHR (95% CI) | Adj. sHR (95% CI) | Adj. sHR (95% CI) | Adj. sHR (95% CI) | Adj. sHR (95% CI) | |
Sex | |||||
Male | Ref | ref | Ref | ref | Ref |
Female | 1.04 (0.96–1.13) | 1.00 (0.92–1.09) | 1 (0.92–1.09) | 0.99 (0.92–1.10) | 1.00 (0.91–1.09) |
Age group (years) | |||||
18–39 | Ref | ref | Ref | ref | Ref |
40–49 | 0.87 (0.62–1.23) | 0.87 (0.62–1.21) | 0.87 (0.62–1.21) | 0.87 (0.62–1.21) | 0.86 (0.62–1.20) |
50–59 | 0.69 (0.51–0.92) | 1.03 (0.77–1.38) | 1.02 (0.76–1.37) | 1.02 (0.76–1.37) | 1.01 (0.75–1.35) |
60–69 | 0.70 (0.53–0.94) | 1.13 (0.85–1.50) | 1.12 (0.84–1.49) | 1.11 (0.83–1.48) | 1.10 (0.83–1.46) |
70–79 | 0.75 (0.56–1.00) | 1.20 (0.90–1.60) | 1.18 (0.89–1.57) | 1.17 (0.88–1.56) | 1.17 (0.87–1.54) |
80+ | 1.15 (0.85–1.55) | 1.53 (1.13–2.06) | 1.50 (1.11–2.02) | 1.47 (1.09–1.99) | 1.46 (1.09–1.97) |
Area remoteness | |||||
Major cities | Ref | ref | Ref | ref | Ref |
Regional | 0.97 (0.88–1.06) | 1.00 (0.90–1.11) | 1.00 (0.90–1.11) | 0.99 (0.89–1.11) | 1.00 (0.90–1.11) |
Remote | 0.98 (0.80–1.20) | 1.11 (0.92–1.34) | 1.10 (0.91–1.33) | 1.10 (0.91–1.33) | 1.12 (0.92–1.35) |
Area level SES | |||||
Q1 (Most disadvantaged) | Ref | ref | Ref | ref | Ref |
Q2 | 0.96 (0.86–1.07) | 0.90 (0.80–1.01) | 0.90 (0.80–1.01) | 0.90 (0.80–1.01) | 0.90 (0.80–1.01) |
Q3 | 0.87 (0.74–1.01) | 0.80 (0.68–0.95) | 0.80 (0.68–0.95) | 0.80 (0.68–0.95) | 0.80 (0.68–0.95) |
Q4 | 0.96 (0.86–1.08) | 0.96 (0.84–1.08) | 0.95 (0.84–1.08) | 0.96 (0.85–1.08) | 0.95 (0.84–1.07) |
Q5 (Least disadvantaged) | 0.86 (0.74–0.98) | 0.82 (0.70–0.96) | 0.82 (0.70–0.96) | 0.81 (0.70–0.95) | 0.82 (0.70–0.95) |
Period | |||||
2003–2007 | Ref | ref | Ref | ref | Ref |
2008–2012 | 0.95 (0.87–1.03) | 0.79 (0.72–0.87) | 0.80 (0.73–0.87) | 0.80 (0.73–0.88) | 0.80 (0.73–0.88) |
Subsite | |||||
Colon | Ref | ref | Ref | ref | Ref |
Rectal | 0.97 (0.89–1.05) | 0.98 (0.90–1.08) | 0.98 (0.90–1.08) | 0.99 (0.90–1.08) | 0.98 (0.90–1.08) |
ACPS stage | |||||
A | |||||
B | 2.79 (2.19–3.56) | 2.68 (2.09–3.42) | 2.67 (2.09–3.41) | 2.66 (2.08–3.40) | 2.67 (2.09–3.42) |
C | 6.56 (5.20–8.28) | 6.19 (4.90–7.82) | 6.18 (4.89–7.81) | 6.13 (4.85–7.75) | 6.17 (4.89–7.81) |
D | 26.1 (20.7–32.8) | 23.8 (18.9–30.1) | 23.8 (18.9–30.1) | 23.7 (18.8–29.9) | 23.9 (18.9–30.2) |
Differentiation | |||||
Well | ref | ref | Ref | ref | Ref |
Moderate | 1.72 (1.27–2.33) | 1.62 (1.20–2.19) | 1.61 (1.19–2.18) | 1.60 (1.18–2.16) | 1.61 (1.19–2.18) |
Poorly/undifferentiated | 3.70 (2.71–5.04) | 2.68 (1.97–3.65) | 2.68 (1.97–3.65) | 2.65 (1.94–3.60) | 2.67 (1.96–3.64) |
Unknown | 5.45 (3.94–7.54) | 3.34 (2.41–4.63) | 3.33 (2.40–4.62) | 3.29 (2.38–4.56) | 3.31 (2.39–4.59) |
CCI score | |||||
0 | Ref | Ref | |||
1 | 1.05 (0.92–1.20) | 0.99 (0.85–1.14) | |||
2 | 1.25 (1.04–1.51) | 1.35 (1.10–1.67) | |||
3+ | 1.24 (0.97–1.59) | 1.07 (0.78–1.48) | |||
ECI score | |||||
0 | Ref | ref | |||
1 | 1.04 (0.83–1.30) | 0.86 (0.66–1.13) | |||
2 | 1.47 (1.29–1.67) | 1.36 (1.18–1.58) | |||
3+ | 1.55 (1.07–2.25) | 1.13 (0.71–1.81) | |||
C3 score | |||||
0 | Ref | Ref | |||
1 | 1.07 (0.95–1.21) | 0.99 (0.87–1.12) | |||
2 | 1.27 (1.12–1.44) | 1.28 (1.11–1.48) | |||
3+ | 1.27 (1.07–1.49) | 1.12 (0.92–1.37) | |||
