Figure 2

fMRI results (A). Behavioural measures of the participants measured by fMRI in terms of changes in pain sensitivity ratings (day 2 - day 1; scale: 0-“no pain at all”, 100-“unbearable pain”). Raw scores are plotted in Supplementary Figure S1. (B) Parameter estimates of peak voxels in the early pain phase for the contrast Pain Day 2 > Pain Day 1 in the anterior cingulate cortex (ACC; 3,38,2), right insula (41,−11,−8), bilateral nucleus accumbens (−9,14,−6/12,8,−12) and bilateral thalamus (0,−14,6/5,−9,9). (C) BOLD signal in the early pain phase for the contrast FLPS(Pain Day 2 > Pain Day 1) > MLPS(Pain Day 2 > Pain Day 1) of the ACC (I, V), the insula (II, IV), nucleus accumbens (III, IV) and thalamus (I, II, V). To better judge the extent of the activations, the display threshold is set to p < 0.005, 10 voxels minimum).