Figure 4 | Scientific Reports

Figure 4

From: Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro

Figure 4

Niclosamide-induced endosomal pH neutralization impairs the maturation of DENV. (a) Western blot analysis of DENV-2 prM and E proteins purified from supernatants treated with niclosamide or DMSO. Uncropped images are presented in the supplemental material. (b) Structural representation of dengue virion and conformation of E proteins. (c) Representative TEM images of DENV particles purified from culture supernatants treated with niclosamide or DMSO.

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