Figure 8
From: gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery
Analysis of PACAP-Rho distribution along BBB capillaries and brain parenchyma after i.v. administration in mice. Analysis of fluorescence parameters inside (inbound column, A,C) and outside (outbound column B,D) BBB capillaries in mouse brain for gH625-Lipo, Lipo and NaCl injected controls. Measure of integrated density O.D. and mean fluorescence O.D. within the blood capillaries of the entire brain volume region of interest (A,C). Measure of integrated density O.D. and mean fluorescence O.D. outside the blood capillaries of the entire brain volume region of interest (B,D). Values represent means ± SEM, (*P < 0.05; **P < 0.005; ***P < 0.0005).
