Figure 4
Oct4 plays a central role in the network of the E3.25 HNC-h-DEGs. (A) Protein binary interaction network of the HNC-h-DEGs. The node colour codifies incidence number (blue, green, yellow and red for incidences 1, 2, 3 and more than 4, respectively). (B) Bar plot of the -log10(p-value) of the significant enriched GO terms of HNC-h-DEGs. Longer bars correspond to higher statistical significance of the enrichment (p-values inside parentheses). The red, green and cyan bars correspond with molecular function, biological process and cellular compartment GO terms, respectively. (C) Chromosomal landscaping of the HNC-h-DEGs. The horizontal blue lines mark the loci of the HNC-h-DEGs, and their length is proportional to the average level of expression of each HNC-h-DEG across all the HNCs. The red asterisk marks the chromosome with statistically significant enrichment of HNC-h-DEGs, hypergeometric distribution p-value < αLAN = 0.01. (D) Zoom-in on chromosome 17, marking the HNC-h-DEG gene names and their loci. The green, red and blue labels mark the clusters on the A3.3, B1 and E4 cytobands, the black labels mark the loci that did not pass the criterion for uni-dimensional clustering of loci.
