Figure 5

Dynamics of the transcriptomics bifurcations across E3.25-LNC, E3.25-HNC, E3.5 and E4.5. (A,C,E,G) Transcriptomics trajectories ordered from earlier to later bifurcation decision. Each trajectory colour corresponds to the level of expression at the earliest time of the trajectory. Bluer colour corresponds to lower expression at the earliest measured time. The histogram of the transcriptomics level of the trajectories is shown on the z-axis at each embryonic day. The two-point passing stages represent a bifurcation of the gene trajectory at such stage, whereas the one-point passing stage represents a continuous distribution of states that cannot be segregated into two modes. (B,D,F,H) Top 12 transcripts with the maximum separation of the bifurcation of their corresponding trajectories, defined by the difference \(\overline{{D}_{g}}\) of the bifurcations means.