Figure 4
Translocation of E. faecalis VE14821cm in clindamycin-treated C57BL/6 and CX3CR1−/− mice. Total enterococcal counts (
) and VE14821cm counts (
) were evaluated in clindamycin-treated C57BL/6J (B6J), C57BL/6N (B6N) and CX3CR1−/− (CX) mice 13 hours after oral inoculation. Each dot represents one mouse (n ≥ 7) and indicates the number of colony-forming units (CFUs) per gram of content (g of content) or per organ. The dotted line represents the detection limit. Horizontal bars represent the median value from two independent experiments. Enterococcal counts in the gut lumen (A) were conducted on luminal content from the small intestine (cSi), the caecum (cCA) and the colon (cCO). Enterococcal counts in the gut tissues (B) were conducted on the small intestine (SI), the caecum (CA) and the colon (CO). Enterococcal counts in the peripheral organs (C) were conducted on the mesenteric lymph nodes (MLNs), the mesenteric adipose tissue (MAT), the spleen (SP), the kidneys (KDs), the liver (LV) and the heart (HR). Statistical analysis was performed using the Mann–Whitney test. Asterisks (*) indicate statistically significant differences between counts (*P < 0.05, **P < 0.01, ***P < 0.001); ns, non-significant difference.
